Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/117158
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- Title
- Efficacy and safety of bimatoprost as replacement for latanoprost in patients with glaucoma or ocular hypertension : a uniocular switch study
- Related
- Journal of glaucoma, Vol. 18, Issue 8 (2009), p.582-588
- DOI
- 10.1097/IJG.0b013e318199722b
- Publisher
- Lippincott Williams & Wilkins
- Date
- 2009
- FoR/RFCD Code(s)
-
110300 Clinical Sciences
- Author/Creator
- Casson, Robert J
- Author/Creator
- Liu, Lance
- Author/Creator
- Graham, Stuart L
- Author/Creator
- Morgan, William H
- Author/Creator
- Grigg, John R
- Author/Creator
- Galanopoulos, Anna
- Author/Creator
- Crawford, Andrew
- Author/Creator
- House, Philip H
- Description
- Purpose: To assess the efficacy and safety of switching patients from bilateral latanoprost to bimatoprost in 1 eye while maintaining latanoprost in the fellow eye. Patients and Methods: This prospective, open-label, multicenter, uniocular (within-eye control) study was conducted from March 2005 to February 2007; 105 patients with glaucoma or ocular hypertension were enrolled. At baseline, patients using bilateral latanoprost were switched to bimatoprost treatment in 1 eye (study eye) and continued latanoprost treatment in the fellow eye (control eye). At 12 weeks, patients were offered bilateral bimatoprost for 12 additional weeks. Results: At week 12, the mean difference in intraocular pressure (IOP) from baseline was -3.0 mm Hg in study eyes and -1.6 mm Hg in control eyes, which equates to a further -1.4 mm Hg (95% confidence limits: -1.9, -0.9) reduction in IOP in study eyes compared with control eyes (P<0.0001). Overall, 27% (28/104) more study eyes had >=-2.5 mm Hg reduction in IOP than control eyes (P<0001). At week 24, the mean difference in IOP from baseline was -2.8 mm Hg for study eyes and for control eyes that had switched to bimatoprost. Conjunctival hyperemia occurred more frequently and was more severe in bimatoprost-treated eyes at week 12 than at baseline (P<0.001). No patients withdrew from treatment because of conjunctival hyperemia. Conclusions: Clinically, these data suggest that switching patients from latanoprost to bimatoprost may result in further improvement in IOP control.
- Description
- 7 page(s)
- Subject Keyword
- 110300 Clinical Sciences
- Subject Keyword
- open angle glaucoma
- Subject Keyword
- ocular hypertension
- Subject Keyword
- bimatoprost
- Subject Keyword
- latanoprost
- Subject Keyword
- prostaglandin analogs
- Resource Type
- journal article
- Organisation
- Macquarie University. Australian School of Advanced Medicine
- Identifier
- http://hdl.handle.net/1959.14/117158
- Identifier
- ISSN:1057-0829
- Identifier
- mq-rm-2009004688
- Language
- eng
- Reviewed
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