Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/116409
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- Title
- Endothelin-1 regulates arterial pulse wave velocity in vivo
- Related
- Journal of the American College of Cardiology, Vol. 42, Issue 11 (2003), p.1975-1981
- DOI
- 10.1016/j.jacc.2003.06.016
- Publisher
- Elsevier
- Date
- 2003
- FoR/RFCD Code(s)
-
110200 Cardiovascular Medicine and Haematology
- Author/Creator
- McEniery, Carmel M
- Author/Creator
- Qasem, Ahmad
- Author/Creator
- Schmitt, Matthias
- Author/Creator
- Avolio, Alberto P
- Author/Creator
- Cockcroft, John R
- Author/Creator
- Wilkinson, Ian B
- Description
- Objectives: The aim of this study was to investigate whether endothelin-1, acting locally, regulates arterial distensibility, assessed by measuring pulse-wave velocity in vivo. Background: Arterial stiffness is a key determinant of cardiovascular risk. Several lines of evidence support a role for the endothelium in regulating arterial stiffness by release of vasoactive mediators. However, the role of endothelin-1 (ET-1) in the regulation of arterial stiffness has not been investigated. Methods: All studies were conducted in anesthetized sheep. Pulse wave velocity (PWV) was calculated using the foot-to-foot methodology from two pressure waveforms simultaneously recorded with a high-fidelity, dual pressure-sensing catheter placed in the common iliac artery. Results: Intra-arterial infusion of ET-1 significantly increased iliac PWV by 12 ± 5% (mean ± STD; p < 0.001), whereas infusion of the endothelin-A (ETA) receptor antagonist BQ-123 significantly reduced PWV by 12 ± 4% (p < 0.001). After BQ-123 infusion, exogenously infused ET-1 did not significantly change PWV compared with infusion of saline (change of −0.08 ± 0.11% vs. −0.01 ± 0.07%; p = 0.53). Importantly, infusion of BQ-123 or ET-1 distal to the common iliac artery did not affect PWV. Conclusions: These results demonstrate, for the first time, that endogenous ET-1 production directly regulates large artery PWV in vivo. In addition, exogenous ET-1 increases PWV, and this can be blunted by ETA receptor blockade. These observations explain, in part, why conditions that exhibit up-regulation of ET-1 are also associated with arterial stiffening. Therefore, drugs that block ETA receptors may be effective in reducing large artery stiffness in humans, and thus cardiovascular risk.
- Description
- 7 page(s)
- Subject Keyword
- 110200 Cardiovascular Medicine and Haematology
- Resource Type
- journal article
- Organisation
- Macquarie University. Australian School of Advanced Medicine
- Identifier
- http://hdl.handle.net/1959.14/116409
- Identifier
- ISSN:0735-1097
- Identifier
- mq-rm-2008003003
- Language
- eng
- Reviewed
