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Determination of aortic pulse wave velocity from waveform decomposition of the central aortic pressure pulse

Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/115803

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Title: Determination of aortic pulse wave velocity from waveform decomposition of the central aortic pressure pulse
Related: Hypertension, Vol. 51, Issue 2 (2008), p.188-195
DOI: 10.1161/HYPERTENSIONAHA.107.092676
Publisher: American Heart Association
Date: 2008
FoR/RFCD Code(s): 110300 Clinical Sciences
Author/Creator: Qasem, Ahmed
Author/Creator: Avolio, Alberto P
Description: Aortic pulse wave velocity (PWV), calculated from pulse transit time (PTT) using 2 separate pulse recordings over a known distance, is a significant biomarker of cardiovascular risk. This study evaluates a novel method of determining PTT from waveform decomposition of central aortic pressure using a single pulse measurement. Aortic pressure was estimated from a transformed radial pulse and decomposed into forward and backward waves using a triangular flow wave. Pulse transit time was determined from cross-correlation of forward and backward waves. Pulse transit time, representing twice the PTT between 2 specific sites, was compared with independent measurements of carotid-femoral PTT in a cohort of 46 subjects (23 females; age 57±14 years). Linear regression between measured PTT (y; milliseconds) and calculated PTT (x; milliseconds) was y=1.05x-2.1 (r=0.67; P<0.001). This model was tested in a separate group of 44 subjects (21 females; age 55±14 years) by comparing measured carotid-femoral PWV (y; meters per second) and PWV calculated using the estimated value of PTT (eTR/2) and carotid femoral distance (x; meters per second; y=1.21x-2.5; r=0.82; P<0.001). Findings indicate that the time lag between the forward and backward waves obtained from the decomposition of aortic pressure wave can be used to determine PWV along the aortic trunk and shows good agreement with carotid-femoral PWV. This technique can be used as a noninvasive and nonintrusive method for measurement of aortic PWV using a single pressure recording.
Description: 8 page(s)
Subject Keyword: 110300 Clinical Sciences
Subject Keyword: pulse
Subject Keyword: aorta
Subject Keyword: arterial pressure
Subject Keyword: digital signal processing
Subject Keyword: blood flow
Resource Type: journal article
Organisation: Macquarie University. Australian School of Advanced Medicine

Identifier: http://hdl.handle.net/1959.14/115803
Identifier: ISSN:0194-911X
Identifier: mq-rm-2008990275
Language: eng
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