Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/113634
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- Title
- The Enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins?
- Related
- FEBS letters, Vol. 584, No. 10 (2010), p.2093-2101
- DOI
- 10.1016/j.febslet.2010.01.027
- Publisher
- Elsevier
- Date
- 2010
- FoR/RFCD Code(s)
-
060100 Biochemistry and Cell Biology
- Author/Creator
- Littler, Dene R
- Author/Creator
- Harrop, Stephen J
- Author/Creator
- Curmi, Paul M.G
- Author/Creator
- Goodchild, Sophia C
- Author/Creator
- Phang, Juanita M
- Author/Creator
- Mynott, Andrew V
- Author/Creator
- Jiang, Lele
- Author/Creator
- Valenzuela, Stella M
- Author/Creator
- Mazzanti, Michele
- Author/Creator
- Brown, Louise J
- Author/Creator
- Breit, Samuel M
- Description
- Chloride intracellular channel proteins (CLICs) are distinct from most ion channels in that they have both soluble and integral membrane forms. CLICs are highly conserved in chordates, with six vertebrate paralogues. CLIC-like proteins are found in other metazoans. CLICs form channels in artificial bilayers in a process favoured by oxidising conditions and low pH. They are structurally plastic, with CLIC1 adopting two distinct soluble conformations. Phylogenetic and structural data indicate that CLICs are likely to have enzymatic function. The physiological role of CLICs appears to be maintenance of intracellular membranes, which is associated with tubulogenesis but may involve other substructures.
- Description
- 9 page(s)
- Subject Keyword
- 060100 Biochemistry and Cell Biology
- Subject Keyword
- chloride intracellular channel protein
- Subject Keyword
- redox
- Subject Keyword
- membrane insertion
- Subject Keyword
- tubulogenesis
- Subject Keyword
- CLIC1
- Resource Type
- journal article
- Organisation
- Macquarie University. Dept. of Chemistry and Biomolecular Sciences
- Organisation
- Macquarie University. Higher Degree Research Office
- Identifier
- http://hdl.handle.net/1959.14/113634
- Identifier
- ISSN:0014-5793
- Identifier
- mq-rm-2010000265
- Language
- eng
- Reviewed
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