Runoff fields over northern Africa (10-25°N, 20°W-30°E) derived from 17 atmospheric general circulation models driven by identical 6 ka BP orbital forcing, sea surface temperatures, and CO2 concentration have been analyzed using a hydrological routing scheme (HYDRA) to simulate changes in lake area. The AGCM-simulated runoff produced six-fold differences in simulated lake area between models, although even the largest simulated changes considerably underestimate the observed changes in lake area during the mid-Holocene. The inter-model differences in simulated lake area are largely due to differences in simulated runoff (the squared correlation coefficient, R², is 0.84). Most of these differences can be attributed to differences in the simulated precipitation (R²=0.83). The higher correlation between runoff and simulated lake area (R²=0.92) implies that simulated differences in evaporation have a contributory effect. When runoff is calculated using an offline land-surface scheme (BIOME3), the correlation between runoff and simulated lake area is (R²=0.94). Finally, the spatial distribution of simulated precipitation can exert an important control on the overall response.