Joint modelling of survival and cognitive decline in the Australian Longitudinal Study of Ageing | Macquarie University ResearchOnline

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Title: Joint modelling of survival and cognitive decline in the Australian Longitudinal Study of Ageing
Related: Journal of the Royal Statistical Society. Series C, Applied statistics, Vol. 60, No. 2 (2011), p.221-238
DOI: 10.1111/j.1467-9876.2010.00737.x
Publisher: Royal Statistical Society
Date: 2011
Author/Creator: Graham, Petra L
Author/Creator: Ryan, Louise M
Author/Creator: Luszcz, Mary A
Description: Article first published online : 26 OCT 2010 The paper describes the use of a longitudinal tobit model to characterize cognitive decline over a 13-year period in a cohort of 2087 elderly Australians. Use of a tobit formulation allows for the so-called ‘ceiling effect’ wherein many subjects achieve perfect test scores. A Bayesian hierarchical joint model is presented that allows for random subject-specific intercepts and slopes, as well as for informative dropout. Results suggest several potential areas of intervention. For example, there is a clear dose–response effect of exercise whereby increasing levels of exercise are associated with higher cognitive scores.
Description: 18 page(s)
Subject Keyword: Bayesian methods
Subject Keyword: Dementia
Subject Keyword: Informative dropout
Subject Keyword: Markov chain Monte Carlo methods
Subject Keyword: Tobit
Resource Type: journal article
Organisation: Macquarie University. Dept. of Statistics

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